Oxidized Cholesterol as a Cause of Alzheimers Disease October 20, 2019 100 By William Morgan CategoryArticlesTagsAlzheimer's disease butter Cholesterol cholesterol oxidation dr greger dr gregor dr michael greger ghee how not to die is butter healthy is ghee healthy michael greger nutrition facts nutritionfacts.org 100 Comments Adler 33 says: May 30, 2018 at 11:48 am Sugar is the enemy as well.. Do not eat refined carbs or sugar with healthy fat diet. Reply D Master says: May 30, 2018 at 11:53 am Coconut oil producers much lower oxidised cholesterol than other oils. That's probably why coconut oil has a reputation for reversing Alzheimer's disease. Reply Eelke Aptroot says: May 30, 2018 at 11:56 am Makes sense it must be oxidized cholesterol, since that cholesterol we make ourselves is rather fresh. Some Hindus ironically refer to ghee as a divine liquid, to some extent that''s correct as it appears to help them to meet their maker… Reply Idylchatter says: May 30, 2018 at 12:03 pm Reversing Alzheimer's coconut oil, CBD, or if you live in one of those states, cannabis. If you have issues with oxidized cholesterol perhaps your antioxidant profile is not what it should be. https://www.ncbi.nlm.nih.gov/pubmed/28217094 Front Pharmacol. 2017 Feb 3;8:20. doi: 10.3389/fphar.2017.00020. ECollection 2017 In Vivo Evidence for Therapeutic Properties of Cannabidiol (CBD) for Alzheimer's Disease. Watt G1, Karl T2 Alzheimer's disease (AD) is a debilitating neurodegenerative disease that is affecting an increasing number of people. It is characterized by the accumulation of amyloid-β and tau hyperphosphorylation as well as neuroinflammation and oxidative stress. Current AD treatments do not stop or reverse the disease progression, highlighting the need for new, more effective therapeutics. Cannabidiol (CBD) is a non-psychoactive phytocannabinoid that has demonstrated neuroprotective, anti-inflammatory and antioxidant properties in vitro. Thus, it is investigated as a potential multifunctional treatment option for AD. Here, we summarize the current status quo of in vivo effects of CBD in established pharmacological and transgenic animal models for AD. The studies demonstrate the ability of CBD to reduce reactive gliosis and the neuroinflammatory response as well as to promote neurogenesis. Importantly, CBD also reverses and prevents the development of cognitive deficits in AD rodent models. Interestingly, combination therapies of CBD and Δ9-tetrahydrocannabinol (THC), the main active ingredient of cannabis sativa, show that CBD can antagonize the psychoactive effects associated with THC and possibly mediate greater therapeutic benefits than either phytocannabinoid alone. The studies provide "proof of principle" that CBD and possibly CBD-THC combinations are valid candidates for novel AD therapies. Further investigations should address the long-term potential of CBD and evaluate mechanisms involved in the therapeutic effects described. Reply Life Mix says: May 30, 2018 at 12:04 pm ok, so now I'd like to know if it can be reversed? and if so at what point is the individual to far gone to change their way of eating. Granted I get the information is saying that this process happens way earlier than the onset. But I'd still like to know when you do. Thank you. Reply Kaztrofy says: May 30, 2018 at 12:06 pm So if polyunsaturated fatty acids like DHA is very good for the brain how can same type of acids found in vegetable oil be bad? What am I missing here? Reply Ronnie & Minh says: May 30, 2018 at 12:07 pm Just eat fresh vegan food, preferably raw. Reply A KT says: May 30, 2018 at 12:10 pm How does cholesterol get oxidized? Im supposing it’s already oxidized before consumed? Isnt oxidation what happens to food when is exposed to oxygen? That’s what causes the Apple interior to turn brown and the fats (ie oils) to oxidize quickly once pulled pressed from food ? Reply Celso Calamba says: May 30, 2018 at 12:16 pm Dr mc gregor thx. Reply Fernando Torres says: May 30, 2018 at 12:17 pm You said not to grill tofu, then is it ok to use the oven or lightly frying it ok? Please answer Reply MzClementine says: May 30, 2018 at 12:27 pm Very interesting. Reply Fatts McGee says: May 30, 2018 at 1:03 pm Great information! Reply MzClementine says: May 30, 2018 at 1:07 pm Could this be a metabolic disorder? Not everyone within the healthy subjects are not eating a super refined healthy diet. So why then are some not able to process the oxysterols, out of the blood stream. Then it’s not metabolic. What about methylation? Wouldn’t this affect the processes as to which one get get the oxysterols out of the system. I feel that it is!!! Reply Scott Bailey says: May 30, 2018 at 1:09 pm Does this mean i should not take krill oil supplements? Reply MrChrisMoo says: May 30, 2018 at 1:11 pm Dr wallach has been pointing out oxidized cholesterol for 30 years. Reply Lynda says: May 30, 2018 at 1:18 pm Dr. Greger Can you make a video on teeth what causes tooth decay and possibly how to keep them healthy? Reply Lichtblick says: May 30, 2018 at 1:21 pm You know what plants don't have? Cholestreol Reply 2 weeks ago says: May 30, 2018 at 1:25 pm Very interesting – thank you! Reply Shari T says: May 30, 2018 at 1:28 pm Thanks for posting this well researched video- very informative!! Reply GlitchLife says: May 30, 2018 at 1:29 pm My Professor is Dr Liliana Calderone, she is credited with finally discovering the cause of Alzheimer's with immutable proof and her study which lasted well over 15 years was published last month. You should read it, has little to nothing to do with diet and the developed disease was found in its early stages in children as young as 7 years of age. Reply Lichtblick says: May 30, 2018 at 1:31 pm It's the food! Reply Peter Faber says: May 30, 2018 at 1:32 pm Maybe you're running to your preferred conclusions. From: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC151135/ Oxysterols and atherosclerosis When added to cultured endothelial cells and arterial smooth muscle cells, oxysterols are cytotoxic and may also induce apoptosis (see Tabas, this Perspective series, ref. 40). Based on such experiments, oxysterols have been suggested to be atherogenic, but the highly nonphysiological conditions used in most experiments preclude strong conclusions. Since oxysterols mimic many of the effects of cholesterol, dietary oxysterols might be expected to be atherogenic, but clear evidence for this is lacking. A great number of studies have been published on effects of dietary oxysterols on experimental animals (for an excellent review, see ref. 41). Of 13 such studies, six indicate a proatherogenic effect, four an antiatherogenic effect, while three show no significant effect. Oxidatively modified LDL, whose proatherogenic effect is usually explained by its internalization via unregulated scavenger receptors, contains 7-hydroperoxycholesterol and its more stable degradation products 7α- and 7β-hydroxycholesterol and 7-ketocholesterol. 7-Hydroperoxycholesterol appears to be the most cytotoxic oxygenated lipid in oxidized LDL (42) and may well be a powerful atherogenic factor. Unfortunately, studies to address this possibility are difficult because of the compound’s great lability. Toxic oxysterols associated with modified lipoproteins may thus represent an additional atherogenic factor, over and above the simple accumulation of cholesterol in foam cells in the developing atherosclerotic lesion. If so, it will be important to consider the role of other oxysterols in modifying this risk. In particular, since the putative antiatherogenic enzyme CYP27 appears to be highly active in human atheromas, it may be that one oxysterol, 27-hydroxycholesterol, participates in a defense mechanism that suppresses cholesterol accumulation in the presence of 7-hydroperoxycholesterol or other harmful lipids. Reply ItsJustLib says: May 30, 2018 at 2:00 pm You are doing such an amazing thing on this channel. Your work is wonderful! Reply Terry Moore says: May 30, 2018 at 2:08 pm Statins…! Reply lockhrt999 says: May 30, 2018 at 2:21 pm As an Indian I find the relation between ghee and cardiovascular diseases very inconclusive. We have saints/gurus in Hindus who consume insane amount of dairy including ghee. Many of these drink more than half litre of ghee everyday. And ask any Indian, almost none of these gurus die before turning 90 and cause of death is always natural. Reply ampoules1 says: May 30, 2018 at 2:24 pm Can the plaques in the brain be cleaned out on a plant diet? Reply sooooooooDark says: May 30, 2018 at 2:40 pm RAW MEATRAW IS LAWWWWWWWSTOP THE BLOATEDNESS – NOW!!!! Reply Paul Ⓥ Gregory says: May 30, 2018 at 2:48 pm If only meat, dairy and egg eaters could remember this Reply TheLetterY says: May 30, 2018 at 3:21 pm I may die prematurely from cancer, heart disease, or a stroke but at least I can tell myself that I ate right, that my plant based diet was the best choice. I won't be plagued with thoughts that I could have done better. It gives me a certain measure of peace. Reply Raja Shahja says: May 30, 2018 at 3:24 pm Those generations that consumed Ghee in india they all lived up to their 90s and above, while our health was SCREWED BY MOTHER FUCKER ALOPATHY DOCTORS who told us not to consume fats liek he i doing here, SUCH BASTARDS ARE Still trying to destroy our lives, BLOODY BASTARDS, VOTE THIS MOTHER FUCKER DOWN and report HIM. Reply Dayle Diamond says: May 30, 2018 at 3:39 pm If the brain oxidizes cholesterol to eject it through the blood/brain barrier, then how is foreign, oxidized cholesterol building up in people's brains? Wouldn't it leave via the same process? Reply NORMLfan13 says: May 30, 2018 at 3:51 pm How can it be legal to sell ppl known class 1 carcinogens like bacon without a warning label like on cigarettes? Reply Adamimmune says: May 30, 2018 at 4:11 pm Concentrated sugar is the main culprit. Dairy is bad too.. Reply Bill Morris says: May 30, 2018 at 4:41 pm Great job, Dr. Greger! Reply Ivail says: May 30, 2018 at 4:47 pm Great upload – thank you! But how about dry fasting(?) – i think the oxidized cholesterol will be cleared very fast by practicing fasting and as the autophagy kicks in following by the new stem-cells which will turn into healthy ones wherever they are needed. Reply Christy M. says: May 30, 2018 at 4:55 pm I’d like more information. What were the cholesterol levels of the patients in the study? And does cholesterol levels matter? Or just the food choices. Reply Renatouki !!!!! says: May 30, 2018 at 4:57 pm thank you very much for the video !!! recently I heard that potatoes, fruit , and oats spike insuline which in turns spile inflammation and then cholesterol comes to the rescue to repair damage in the arteries due to the inflammation ! and that organic meat doesn’t release too much insuline when consumed without carbs and that the real cause of atherosclerosis is calcium built up and not cholesterol !!! (the percentage is quite low ) to put it in other words people doing strict keto and interim fasting have very good blood test results !! and does interim fasting burdens kidneys ??? CONFUSION !!!! Reply SuperAtheist says: May 30, 2018 at 5:13 pm Did I miss the video(s) on intermittent fasting? . Reply haku says: May 30, 2018 at 5:18 pm scientific evidence 0p Reply Some Guy says: May 30, 2018 at 5:18 pm One of my favourites so far. Great video! Reply justgivemethetruth says: May 30, 2018 at 5:20 pm Under what conditions was the cholesterol more concentrated in the vein from the brain than the artery to the brain? Meaning there was more going into the brain than coming out. How and when did this happen? Was it a constant, or just after a meal with say Parmesan cheese or whatever? Was it universal across all participants in the study and over time? And why have I always heard that cholesterol in one's food has little to do with cholesterol in one's blood? Then, is there any way to get out of your body these things in your veins? Reply Natty Bumppo says: May 30, 2018 at 6:20 pm Mind=blown Reply Peggy Harris says: May 30, 2018 at 6:29 pm India began to experience problems as they assimilated the Western diet into their culture. Ghee whiz…its obvious. Reply Paul Clanner says: May 30, 2018 at 6:46 pm I only have 1 comment about your facts – MOST of them come from studies done from 2000 onward. Hasn't more recent (hence better information) studies been completed? Couldn't you put a cap and refuse to use information sourced pre-2010 and make all your information time relevant and more specific? Love the show but the time issue makes me think that there is better information you could be using. Reply Joe Ochoa says: May 30, 2018 at 6:47 pm My bacon and eggs in the morning will have to change. Great vid. Reply Craig Castanet, D.C. says: May 30, 2018 at 6:53 pm Dr. Gregor says the lowest rates of Alzheimer's in the world, is in India. Yet they have high levels of oxidized cholesterol? Reply 24hourbalance says: May 30, 2018 at 7:14 pm my grandad has alzeimer for 4-5 years now. He used to have plenty of vegetables from his own garden and he didn't eat much meat/fish as he didn't like it. However he ate milk and cheese. Reply Coacervate Droplet says: May 30, 2018 at 7:41 pm The antioxidants in plants slow down the oxidation so IF you are still addicted to animal products try to get more fruits and veg into your diet too. Reply justgivemethetruth says: May 30, 2018 at 7:49 pm OK, put this to the test, what is the controlled for variation between the incidence of Alzheimer's in vegetarians, or people who do not eat the stuff mentioned here, and those who do? What is the number as they compute it, as they find it in the world? What are other parallel factors that might be interfering or causing these results? What is the difference in incidence between those with the Alzheimer's gene, and was that controlled for in this study? One copy of the APOE4 gene variant raises the risk of Alzheimer's by two to three times. Reply alicia ali says: May 30, 2018 at 8:06 pm Please can you address much debated issue about vitamin b 17, or apricot kernel , it’s effectiveness against cancer and people of Hunza Pakistan , where most of their food comes from apricot kernel. Reply oldemail says: May 30, 2018 at 8:34 pm I thought India had virtually no alzheimers Reply Maureen K says: May 30, 2018 at 8:50 pm Another amazing video. Reply Adam says: May 30, 2018 at 9:41 pm I really want to see the rates of oxidized cholesterol in fried foods and vegetable oils Reply Adam says: May 30, 2018 at 10:13 pm The range for commercial spray dried eggs is amazing! What are the main offenders (foods) in the high range? Reply Peter B. Sims says: May 30, 2018 at 11:10 pm Let's put it to the test! Thank you, Dr. Greger Reply Wak Job says: May 30, 2018 at 11:19 pm Dr. Peter Glidden has been talking about this for years. Reply Pat's Public Health says: May 31, 2018 at 1:01 am Fantastic video and information. Reply Coswagrigus says: May 31, 2018 at 1:03 am Oh no, my whole diet is this Reply fцику мцику says: May 31, 2018 at 1:19 am I found this video very enlightening. And I also found this video very enlightening. Reply admin8446 says: May 31, 2018 at 1:32 am 1. What explains the near absence of Alzheimer's disease in india? 2. Has ghee actually been shown as associated with Alzheimer's disease? Reply Anna M. says: May 31, 2018 at 1:33 am Smart guy with strange voice Reply MrIridium192 says: May 31, 2018 at 1:48 am Dr. Greger, thank you for useful & informative videos you provide! Can you make a video about, so called, "Ketogenic" diet? Would greatly help to diffuse some of the confusion… Thank you very much! Reply Simon Cavenagh says: May 31, 2018 at 1:49 am Another opinion piece by the food industry…. Reply Apocalyps says: May 31, 2018 at 1:53 am Good god. Very helpful facts. Also, please reduce the excessive "eehhhhhgggg" sound effects prior to making every 2-3 sentences as it makes you appear to be staged or another proper mole for the opposite side to denounce. Reply andresanchez2000 says: May 31, 2018 at 3:01 am So does this mean that theoretically, even if someone is eating a plant based diet and has high cholesterol it won't be able to enter the brain because it isn't oxidized? Reply BillyBob says: May 31, 2018 at 3:16 am Thank you Dr. Gregor for explaining the science, as you always do. This video is going to be watched by everyone in my family, because it hits close to home for all and I've a big crew. Please keep up the fantastic work you're doing! I look forward to shaking your hand some day in person. Reply Disa Jardine says: May 31, 2018 at 3:58 am Hiya Doc! Great vid! Quick Q for you: I know you've shown that heart disease has ravaged the sub-continent of India, but has Alzheimer's disease also been spiking at an equal rate there? I mean, the data suggests that there would be a positive correlation, right? But is it actually the case? Thanks kindly! 👍💜 Reply ASMRyouVEGANyet? says: May 31, 2018 at 4:54 am My friend helped her dad reverse his Alzheimer's by switching him to a plant-based diet. It's incredible! Reply Maggic says: May 31, 2018 at 5:31 am I think I’m going to give the raw vegan diet a try at least for two weeks every months to detoxify the body. Reply GrimShizuri says: May 31, 2018 at 6:51 am This is a very misleading video. It uses old science, that eating cholesterol will cause high blood cholesterol. This has been debunked many times. https://www.health.harvard.edu/blog/panel-suggests-stop-warning-about-cholesterol-in-food-201502127713 It’s the same as saying that if you eat leafy green vegetables (the healthiest food on the planet) you will turn green. Reply Azarah Eden says: May 31, 2018 at 7:21 am SPARE ME THE BULLSHIT , DR EGO 🤣🤣🤣🤣🤣🤣 Reply Ellie Larkin says: May 31, 2018 at 7:36 am sugar Reply One Journey says: May 31, 2018 at 7:58 am 🎬 1 🤔 🧐 🎥 📽 🎞 🗣 🎙 🧐 Outstanding, thank you so much for sharing. 🌎🌍🌏 Reply Chase Sage says: May 31, 2018 at 10:05 am I call you Doctor MacGregor…like a Scotish warrior King…providing a safe haven for your followers. Thank you! Reply DanoKruz says: May 31, 2018 at 10:11 am Is there anything we can eat ?? Reply tony leung says: May 31, 2018 at 10:23 am Ideally the table of COPs @2:47 should have consistent units for comparison rather than a mixture of ppm, μg/g, mg/100g. I believe the conversion would be: 10 ppm = 10 μg/g = 0.01mg/g = 1mg/100g (pls correct if wrong). This would make sundried shrimp (181 μg/g) worse than tuna. Machaca (dried beef) would be 49 μg/g and chicharron (deep fried pork rinds) 51 μg/g. Reply Randal B says: May 31, 2018 at 12:15 pm Eggs and cheese are bad for you but mercury and aluminum filled vaccines are harmless? Really??? come on. Lost all respect after the vaccine videos. Reply Daniel Rose says: May 31, 2018 at 12:46 pm The implication is that meats and eggs are necessarily bad for you, when perhaps the real problem is how they are cooked and with no antioxidants present? Not saying one should eat a lot of those, but beef liver is like eating a vitamin / mineral pill. And cooking scrambled eggs with added water and low temperatures so that it comes out like custard, and perhaps adding antioxidants to it, like elderberry concentrate, may minimize the oxidized stuff in the food. It works for me. I always add water to cooking pretty much anything. It makes clean up very easy as well. ?? I mostly cook liver and onions maybe 3 times per month and eggs more frequently, as they have so many good things in them. Reply sheila cherotich says: May 31, 2018 at 1:50 pm Hi doc. I'm taking femiplan pills to balance my hormones.i tried to reach you through your web in vain. Can i take fenungreek powder to increase my breasts? Without interfering with my hormones Reply Hi Technique says: May 31, 2018 at 3:42 pm Well I guess I'll throw out my ghee Reply Rita Wing says: May 31, 2018 at 4:10 pm What's the prevalence of Alzheimers in India? I see inflammation is cited as a cause of depression and possible Alzheimers link in Nature just this issue. Reply TheToberman1 says: May 31, 2018 at 6:34 pm Not on this topic, but have you addressed the research that showed the possibility of staph aureus as the cause of Type 2 Diabetes? I’d love to hear your thoughts on that. Reply sunny pepper says: May 31, 2018 at 8:55 pm But rural India has the LOWEST rate of Alzheimer's? Here: https://nutritionfacts.org/2015/11/12/where-are-the-lowest-rates-of-alzheimers-in-the-world/ Reply Ishmael says: June 1, 2018 at 10:56 am Dr. Greger, nice vid! Could you please do a video about Barley Grass? I've heard a lot of good things about it but just how much evidence of its benefits are there? Reply Lisa Lightning says: June 2, 2018 at 7:54 am They do mention diet on the Alzheimer's website, but it should be first and foremost! Reply sh eryty says: June 2, 2018 at 11:48 am what is the program that you use to do the videos? Reply DANG JOS says: June 3, 2018 at 7:12 pm He didn't mention the very low oxidized cholesterol in salmon. My guess is this is because of the astaxanthin in the fish (which colors it pink). Astaxanthin is an antioxidant that perhaps reduces the oxidation of cholesterol. Reply Chami KS says: June 3, 2018 at 11:38 pm If this is true most old people in India must be getting Alzheimers … since ghee is used widely Reply Christy M. says: June 4, 2018 at 12:02 am Thank you, Jenny. I’m going to try that! Reply Rafael Rosas says: June 7, 2018 at 10:50 pm I liked to check the references, thanks Reply odizzido says: June 11, 2018 at 3:36 am hmmmmm. Well, maybe this can be a factor. This was a good presentation on this disease I thought https://www.youtube.com/watch?v=twG4mr6Jov0& Reply ANOMALY RESEARCHERS UK says: July 6, 2018 at 7:13 pm your brain needs fat to work… https://www.google.com/search?q=your+brain+needs+cholesterol&ie=utf-8&oe=utf-8&client=firefox-b Reply Winn M says: July 16, 2018 at 12:33 am Thank you so much for all you do! Reply InquilineKea says: July 19, 2018 at 11:29 pm I don't get why people FRY their eggs…. Reply InquilineKea says: July 19, 2018 at 11:30 pm What about fried eggs? Reply Patrick Wilken says: July 31, 2018 at 9:19 pm So what are the relative rates of Alzheimer's disease in vegans vs vegetarians vs meat eaters? Reply toodeepman says: August 9, 2018 at 2:59 am There appears to be a link with herpes viruses 6 and 7 and alzheimers disease; and using antivirals in the treatment of Alzheimer's disease. That led me to think if there was a connection between oxidized cholesterol and the prevalence of herpes viruses? Big Pharma would be excited at the thought of treating a symptom, the herpes viruses with antivirals. It's certainly not going to explore a connection between herpes viruses and oxidized cholesterol as the cure would be simply to change to a whole plant based diet, Once Again showing the benefits of it. I think this warrants further exploration? Reply Im Estia says: October 22, 2018 at 5:29 am If you clarify your butter under 60°Celsius does it oxidase the cholesterol? Reply Simon Liebe says: January 27, 2019 at 4:16 am I have since some time been a fan of dr Greger and maybee still am. But recently i came across some critique of the book how not to die for being an examples of cherry picking and that the epidemiological studies includes in dr Greger evidence is not really evidence since it is just correlational. It would ve Useful to focus how big the effects in the rct:s are in a because thats the other critique; they are sometimes too small to conclude or dare to suggest that some food may leed to some deseases. So i would apptecciate to understand how big the risk are really with some "bad diets" brought up here, not just indications based on correlations. Thanx for a.. Great.. Video.. I think!But.. For example in the case above: does not the oxidation level go down by the body's own mechanisms later on? And what are the figures of ahlzeimers among vegans compared to non vegans, and are the global health lifestyle between these two group really the same? Reply katakis1 says: September 22, 2019 at 1:17 pm Bring it on Dean Ornish! Can't wait for the Alzheimer's reversal study to be released. Reply Leave a Reply Cancel reply Your email address will not be published. Required fields are marked *Comment Name * Email * Save my name, email, and website in this browser for the next time I comment.