Obesity & Diabetes Explained: The Overflow Phenomenon

Obesity & Diabetes Explained: The Overflow Phenomenon

August 5, 2019 100 By William Morgan


In my last video, I talked about how despite
what some authorities may say, Type 2 diabetes
does not have to be a chronic and progressive
condition as clearly evidenced by the fact
that Doctors like Jason Fung, David Unwin,
Sarah Hallberg, and Ted Naiman just to name
a few have been reversing people’s diabetes
with fasting or a low carb or ketogenic diet.
While some people might be suspicious of a
new fad diet supposedly reversing diabetes,
low carb isn’t actually new at all, nor
is the concept of using it to reverse diabetes.
Dr. Richard Thomas Williamson wrote in his
1898 book “Diabetes Mellitus and Its Treatment”
: that “Potatoes should be excluded from
the diet first, then bread, and gradually
all carbohydrates should be cut off.”
In 1797 military surgeon John Rollo released
a book that described how he treated diabetes
with a carbohydrate restricted meat diet.
Referring to this, Dr. Williamson wrote “Ever
since Rollo published his book on diabetes
in 1797, and pointed out the value of restriction
of the carbohydrates in the food, it has been
acknowledged that of all forms and methods
of treatment this dietetic one is the most
important.”
Interestingly, the concept of “grain avoidance”
or bìgǔ, (also known as BIGU) has been around
for more than 2000 years, going back to the
Han dynasty.
Someone named Wáng xuán hé wrote in around
the year 680AD that “before the times of
farming, ancient people did not eat grain,
so they were long lived.” Not that this
is a medical paper of course, but it’s interesting
that people were specifically avoiding grain
more than a millenium ago.
Eastern Jin Dynasty scholar Ge Hong claimed
that there was not one fat person among those
practicing bìgǔ for spiritual reasons.
Before I get into discussing recent concerns
about low carb diets, we need to look in more
depth at how carbohydrate is a factor in the
development of diabetes. Based on the work
of Dr. Ted Naiman, Dr. Jason Fung and Ivor
Cummins, the path to developing diabetes looks
something like this:
-First, something is filling up your fat cells,
making you fat.
-More specifically, something isn’t just
filling your fat cells up with fat, it’s
pinning that fat there and preventing it from
being pulled out of the fat cell to be burned
up for energy.
-As we discussed last time, this thing filling
up your fat cells is insulin. Insulin is an
anabolic hormone that has many functions,
but one is that it acts as your “fat storage”
hormone and by inhibiting three important
enzymes, it prevents you from burning fat.
-Simply put, the more insulin you have floating
around, the harder it is to empty your fat
cells and the fat builds up.
“And the big question is why did you fill
up your adipocytes. Why are they all full?
Is it because humans shouldn’t eat fat? No.
You filled up your fat cells, because you
suck at burning fat because you eat too much
glucose… you’re eating carbs and glucose,
you’re not burning fat, it accumulates, you
fill up your adipose.”
-What Dr. Ted Naiman said here is easy to
follow because glucose which comes from carbohydrates
raises insulin more than protein and much
more than dietary fat. However, in this presentation,
Dr. Naiman talks about another phenomenon
usually called the Randle cycle. This is where
independent of the action of insulin, glucose
prevents the burning of fat all by itself.
And it makes sense that you’d want to preferentially
burn glucose over fat because you need to
be able to quickly sort out incoming glucose
first since there’s not many places to put
it.
Depending on the person you can store a couple
hundred grams of glucose across your muscles
and liver as glycogen, but if you don’t
empty your glycogen by from the liver by not
eating carbohydrate long enough and you don’t
empty muscle glycogen by doing enough exercise,
that tank of glycogen will fill up.
At this point there’s nowhere to put incoming
carbohydrate, so insulin has to turn it into
fat via a process called de novo lipogenesis
so it can be stored in the only place available:
your fat cells.
Dr. Naiman presents a model for how this works
“But as you add carbohydrates and raise glucose,
you literally have to switch your metabolism
over and burn more glucose just to get rid
of it. In fact if you eat enough carbohydrates
and glucose, you literally have to convert
it to fat via de novo lipogenesis. Only when
carbohydrates and glucose are absent can you
switch your fuel mixture over and burn fat
again.”
This highlights how dietary fat can also be
very fattening, if you eat it with a enough
carbohydrate because the carbohydrate will
prevent you from burning that fat and the
insulin release will hold the fat in storage.
So, to put this together: if you eattoo much
low fiber carbohydrate too frequently, it
will interfere with your ability to burn fat
and fat will accumulate. As your fat cells
get more and more filled with fat, you’ll
need more insulin to hold that fat in place,
making your fasting insulin very high – kind
of like needing more force to cram more stuff
in your suitcase. And these higher levels
of insulin worsen the whole cycle making you
more resistant to insulin, meaning glucose
is harder to process because there’s basically
nowhere to put that glucose – you can only
make energy from glucose at a certain rate,
and your glycogen stores were filled up a
long time ago, so the glucose needs to be
turned into fat for storage, but your fat
cells are already filled up. So at this point,
where do you put the incoming glucose and
fat??
Unfortunately it just overflows into the abdominal
cavity, the liver, the muscle and the pancreas.
The pancreas seems to be the last place that
the fat accumulates, and when the pancreas
is stuffed with fat, the beta cells stop functioning
properly.
Whereas your beta cells were initially pumping
out a ton of insulin to make everything I
just mentioned happen, now that the beta cells
have become dysfunctional, they stop properly
producing insulin, then your insulin levels
drop drastically meaning glucose can’t be
dealt with, so you get diabetic level blood
sugar and then you’re prescribed insulin injections
to keep the blood sugar down but that makes
it even harder to empty the fat cells, so
the situation gets worse and worse .
Keep in mind that as Ivor Cummins points out
in this talk, there are other unhealthy lifestyle
factors that can worsen this insulin resistance
and worsen this whole situation – things like
insufficient sleep, smoking, and poor omega-3
to omega-6 ratio. Maybe the worst is fructose,
a component of table sugar that directly worsens
insulin resistance in the liver.
“Soda and other sugary drinks are the only
individual food that’s actually directly linked
to obesity. Everyone seems to think a day
without orange juice is like a day without
sunshine. Juice is just like soda. There is
no difference. When you take fruit and you
squeeze it, you throw the fiber in the garbage,
that was the good part of the fruit.”
So depending on the person, they might be
fine and insulin sensitive eating spaghetti
carbonara twice a day for many years if they’re
not drinking too much fruit juice or sugar
sweetened sodas and have these other factors
in order.
Before we move on let me present two pieces
of evidence for the overflow phenomenon. Going
back to Dr. Ted Naiman’s talk, he gives
an excellent example of overstuffed fat causing
insulin resistance: People with lipodystrophy.
this is a disorder where you have hardly any
subcutaneous fat – So these people barely
have any space to safely store any fat. So
where does new fat go?
“But The visceral fat is completely maxed
out, and almost everyone with lipodystrophy
has horrible insulin resistance and horrible
brittle diabetes”
This could explain the peculiar situation
in Japan, where despite having a very low
obesity rate of about 3.7%, their rate of
diabetes is 7.6%, only 2% lower than America’s
9.4% , but America’s obesity rate is about
30%. The people of Japan and other asian countries’
difficulty getting fat could ironically be
making them more susceptible to diabetes and
insulin resistance because they have less
safe storage space for fat.
So what happens if you give an insulin resistant
person a new place to store fat ? There was
a study that tried just that. They got some
lipodystrophic mice with diabetes. Then Surgically
implanted some fat tissue under the mouse’s
skin, and connected it to their blood supply
and then, having a new place to put fat cleared
up the road block and magically cured insulin
resistance in these mice.
So, given all this, fixing these other factors
Ivor Cummins talked about and by fasting or
going on a low carbohydrate diet so you get
the insulin down and the fat burning up would
make the most sense as a line of treatment.
But,
You surely saw articles about that study showing
that low carb diets are bad for longevity.
Though, as Nina Teicholz points out, this
study was based on a simple fill in the dot
questionnaire, similar to this one, which
queried the participants on on only 66 foods.
What if you don’t happen to eat these particular
vegetables? The data gets left out. What if
you eat a bunch of pizza and energy drinks,
it’s not on the list so that data is left
out too.
As Teicholz explains: “Further, the ARIC
participants’ eating habits were tracked
only twice, from 1987-89 and 1993-95. After
1995 the study’s participants were assumed
to have continued eating the same diet for
the next 15 years.”
Finally, Diet questionnaires are inherently
unreliable since most people aren’t tracking
precisely what they ate in what amount. Especially
in this case, you can’t hope to be precise
with this kind of questionnaire. Can you remember
how many times per month you ate bananas,
broccoli and chicken over the past year??
On the other hand, this study, published last
year in the same journal found the exact opposite
result.
The study concluded that “High carbohydrate
intake was associated with higher risk of
total mortality, whereas total fat and individual
types of fat were related to lower total mortality.
Total fat and types of fat were not associated
with cardiovascular disease, … whereas saturated
fat had an inverse association with stroke.
Global dietary guidelines should be reconsidered
in light of these findings.”
Next, you may have heard that top US cardiologist
Kim Williams was saying just last month that
“No one should be doing the ketogenic diet.”
His argument is based on a 2013 systematic
review of 17 studies that found low-carbohydrate
diets to be associated with an increased risk
of heart disease and death.
So, I went ahead and took a look at these
17 studies which by the way are based on questionnaires.
First of all, let me point out that none of
these studies even mentioned a ketogenic diet.
One study specifically said “Our results
do not support a clear, general association
between LCHP score and mortality.” And four
studies actually showed better health outcomes
with carbohydrate reduction, particularly
high glycemic carbohydrates which would be
the ones that raise insulin the most.
Maybe most importantly, several of these studies
did not state the specific carb intakes so
for those we have no idea if people are eating
an actual low carb diet or just eating “less
carb than most people.” This is very important,
because many of the benefits of low carb and
keto arise only when you sufficiently restrict
carbohydrate and get your insulin low enough.
The ten studies that did clearly state carb
intake showed that the diets were not actually
low carb or keto at all. Low carb typically
allows a maximum of 60g of carbohydrate or
around 10% of your daily calories from carbs,
and the ketogenic diet only allows 5% of your
calories from carbs. Two studies only went
as low as 25% of calories from carbs and the
remaining seven six didn’t even get below
30% – this a three times higher carb intake
than what is actually considered “low carb,”
and 6 times higher than ketogenic diet.
So this data being used to criticize ketogenic
diets is not actually data on ketogenic diets
or even low carb diets.
On the other hand we have a study looking
at 83 obese people on a proper ketogenic diet
for 24 weeks. By the way, the diet was administered
to the patients, data was not based on questionnaires.
It concluded: “The present study shows the
beneficial effects of a long-term ketogenic
diet. It significantly reduced the body weight
and body mass index of the patients. Furthermore,
it decreased the level of triglycerides, LDL
cholesterol and blood glucose, and increased
the level of HDL cholesterol. Administering
a ketogenic diet for a relatively longer period
of time did not produce any significant side
effects in the patients.”
And there’s plenty more studies that showcase
the beneficial effects of a ketogenic diet
– I’ve put links to a couple dozen of them
in the description.
So as we’ve seen, based on how diabetes
develops, a low carb or ketogenic diet would
be the most logical approach to treating it,
yet people are constantly advised against
it. Another approach this video unfortunately
didn’t get to touch on is fasting- this
is another excellent way to lower insulin,
increase fat burning and restore insulin sensitivity.
This is mentioned in Jason Fung’s book the
diabetes code.
You may still have several concerns regarding
low carb or ketogenic diets and you may just
now be thinking about concerns you have about
fasting. As I’ve covered many of these points
in previous videos, take a look at the description
for links to relevant videos and more information.
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