How to Lose Weight with Metformin; PCOS; Nondiabetics

How to Lose Weight with Metformin; PCOS; Nondiabetics

July 31, 2019 64 By William Morgan


Hello. This is Ford brewer. I’m doing
a series on metformin . why? metformin has become very popular over the past few
years . it’s by far the number one recommended drug for the first level of
diabetes it’s the number one recommended drug by the American College of
Endocrinologists and the American Diabetic Association but that’s not why
I’m doing a series on it I use it a lot because of insulin resistance
pre-diabetes you have to remember my my population heart attack and stroke
prevention two-thirds of three-quarters of the heart attacks and strokes that
are occurring in my population and in this country overall are occurring
because of insulin resistance and even full-blown diabetes if you remember the
the concept that over half of us get insulin resistance during our 50s then
you start realizing how prevalent it is then you realize that not only do most
insulin resistant folks not realize that even a third of full-blown diabetics
don’t realize it when you start looking at what I’m dealing with what I’m
looking for cleaning this plaque out of arteries and slowing down this
inflammation of plaque and realizing that three-quarters of that plaque is
being caused by having blood sugar levels that are too high then again you
start realizing the importance of medications like metformin metformin is
actually this this video however is on weight loss and metformin
my patients will routinely come in with an OGTT, oral glucose tolerance test of
150 or higher and evidence that they’ve had that for decades and yet no notice
of that by their docs I understand why and we can talk about that in other
videos but a blood look level of 140 glucose
has been shown clearly to cause damage to eyes tendons pancreas kidneys and
arteries as we just as demonstrated well so again that’s why you begin to see the
importance of a medication like metformin
very common and the usual first recommendation that we have is to change
lifestyle to improve diet and exercise but when you read books like why we get
fat and what to do about it other a blood sugar 101 some of these
books show some clear evidence that of a concept that we don’t get fat because we
eat too much we eat too much because our metabolism our genetics and our age are
making us fat it may sound like an excuse but just read up on it study it
before you argue that so again quite often we’ll always start with lifestyle
but quite often these patients need metformin sometimes pioglitazone is an
option when they go on metformin they routinely lose weight why glucose
metabolism is a very complicated thing glucose first in terms of what we’re
looking for it starts in the GI tract it’s absorbed it goes into the blood
goes to the liver is released and then you’ve got glucose in the blood trying
to get inside the cell it goes through the cell membrane and this is either in
the liver or them so then it gets inside the cell once it
gets inside the cell that’s transported to the mitochondria what is the
mitochondria the mitochondria is the powerhouse of the cell and it’s got a
lot of things going on in it but it makes the majority of our energy it
starts burning glucose in a process called glycolysis now there are things
like the enzymes like AMPK which are critical to the multiple processes in
this area metformin results in improvement and amplification of ampk
ampk and other metabolic activities down these pathways and Cascades seem to get
old and rusty as we get older and metformin tends to amp these activities
back up so we start burning fat instead of storing it we start taking sugar out
of the blood we start recycling cellular wastes to burn them it’s a process
called Altaf AG again multiple areas along these steps of glucose metabolism
are improved by metformin now having said all of that there’s evidence that
the biggest impact from from metformin is just stopping the the – what we
call gluconeogenesis dumping of glucose back into the bloodstream by the liver
we’ll talk about that later too but again it’s clear glue on metformin can
talk and cause weight loss even in non diabetic patients now having said that
consider the fact that insulin resistance or pre-diabetes
is so grossly under diagnosed in this country it sort of fogs the term when
you say metformin results in weight loss for non diabetics the resultant weight
loss for folks even without glucose metabolism problems some of the most
challenging patients of polycystic ovary disease now many of those do have
glucose metabolism problems patients on psychiatric medications
there have been studies with middle-aged females that did not have known glucose
metabolism problems again time and time and time again metformin did result in
improved weight loss improved metabolism of glucose now we’re going to have it
again a series of videos on metformin this one was on weight loss we’ll also
talk about a neurologic function and performance dementia senile dementia is
being called by many people type 3 diabetes it seems to be very much
related to impaired glucose metabolism metformin has been shown to help
metformin has been approved for research in anti-aging by the FDA – a researcher up
at Einstein College in New York Einstein Medical School a fellow named
Barzilai so we’ll be looking at anti-aging neurologic performance in
this video we looked at weight loss cardiovascular performance of prevention
and of course in insulin resistance in us baby boomers but there’s even one
other thing prevention of cancer so a lot of things going on with metformin
we’ll have a series on that thank you for your attention