How Ketamine Works for Chronic Pain

How Ketamine Works for Chronic Pain

August 3, 2019 1 By William Morgan


How does ketamine work for chronic pain?
First off, when we say the words “chronic
pain,” that can refer to many different types of pain.
What happens, studies have shown, is that
patients with chronic pain have decreased
neurons and synaptic connections.
In particular, in the prefrontal cortex and
the hippocampus.
Ketamine seems to go in there and increase
the activity of Brain Derived Neurotrophic Factor,
allowing for neurogenesis and synaptogenesis
in those areas that have become diminished
over time from chronic pain.
The other factor is, the pain receptors in
some forms of chronic pain, have seemed to
have gotten over-sensitized or hypersensitized,
meaning they’re much more reactive to receptors
or stimuli than the normal receptor.
Ketamine actually goes in there, in particular,
in the NMDA receptor, and stops the activity
of those hypersensitized or wound up pain
receptors.
So, those are 2 mechanisms of how ketamine
may be working from a biological/biochemical
level on pain.
What do you think about this?
And if you have any questions, leave me a
message or comment below.